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References: References: 1. Six RH, Geurden T, Carter L, et al. Evaluation of the speed of kill of sarolaner (Simparica^™) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Vet Parasitol. 2016;222:37-42. 2. Six RH, Everett WR, Young DR, et al. Efficacy of a novel oral formulation of sarolaner (Simparica^™) against five common tick species infesting dogs in the United States. Vet Parasitol. 2016;222:28-32. 3. Tickborne diseases. National Institute of Allergy and Infectious Diseases website. https://www.niaid.nih.gov/diseases-conditions/tickborne-diseases. Updated March 4, 2016. Accessed April 20, 2017. 4. CAPC guidelines: Ticks for dogs. Companion Animal Parasite Council website. https://www.capcvet.org/guidelines/ticks/. Updated April 4, 2017. Accessed April 20, 2017. 5. Mapping Lyme disease enzootic risk and linking to disease outcomes in the United States. Yale School of Public Health website. https://publichealth.yale.edu/emd/research/zoonosis/projects/tick.aspx. Updated June 26, 2013. Accessed April 21, 2017. 6. Centers for Disease Control and Prevention. Tickborne diseases of the United States. A reference manual for health care providers. Third edition, 2015. https://www.cdc.gov/lyme/resources/tickbornediseases.pdf. Accessed April 21, 2017. 7. Life cycle of hard ticks that spread disease. Centers for Disease Control and Prevention website. https://www.cdc.gov/ticks/life_cycle_and_hosts.html. Updated June 1, 2015. Accessed April 21, 2017. 8. Little SE. Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. Proceedings of the 2nd Canine Vector-Borne Disease (CVBD) Symposium; April 25-28, 2007; Sicily, Italy. http://www.cvbd.org/fileadmin/media/cvbd/Proceedings_CVBD_2007_FINAL23042007.pdf. Accessed April 21, 2017. 9. CAPC guidelines: Fleas for dogs. Companion Animal Parasite Council website. https://www.capcvet.org/guidelines/fleas/. Updated November 1, 2016. Accessed April 21, 2017. 10. Typhus. MedlinePlus website. https://www.nlm.nih.gov/medlineplus/ency/article/001363.htm. Updated April 4, 2014. Accessed April 21, 2017. 11. Plague. World Health Organization website. http://www.who.int/topics/plague/en/. Accessed April 21, 2017. 12. Bartonella. Lymedisease.org website. https://www.lymedisease.org/lyme-basics/co-infections/bartonella/. Accessed April 21, 2017.

_{For animal use only.}

_{SIMPARICA 5 mg (chewable tablets for dogs). Reg. No.: G4317 (Act 36/1947). Each chewable tablet contains 5 mg sarolaner.}_{SIMPARICA 10 mg (chewable tablets for dogs). Reg. No.: G4322 (Act 36/1947). Each chewable tablet contains 10 mg sarolaner.}_{SIMPARICA 20 mg (chewable tablets for dogs). Reg. No.: G4318 (Act 36/1947). Each chewable tablet contains 20 mg sarolaner.}_{SIMPARICA 40 mg (chewable tablets for dogs). Reg. No.: G4319 (Act 36/1947). Each chewable tablet contains 40 mg sarolaner.}_{SIMPARICA 80 mg (chewable tablets for dogs). Reg. No.: G4320 (Act 36/1947). Each chewable tablet contains 80 mg sarolaner.}_{SIMPARICA 120 mg (chewable tablets for dogs). Reg. No.: G4321 (Act 36/1947). Each chewable tablet contains 120 mg sarolaner.}_{For “WARNINGS” refer to the approved package insert. For full prescribing information refer to the package insert approved by the medicines regulatory authority.}

_{Full product information available from Zoetis South Africa (Pty) Ltd., Co. Reg. No.: 2012/001825/07. 6th Floor, North Wing, 90 Rivonia Road, Sandton, 2196. PostNet Suite 53, Private Bag 9976, Sandton, 2146, South Africa. Tel.: +27 11 245 3300 or 0860 ZOETIS (0860 963847). www.zoetis.co.za}